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KMID : 0355620100360010016
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Journal of Korean Association of Oral and Maxillofacial Surgeons
2010 Volume.36 No. 1 p.16 ~ p.22
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The effect of hyaluronic acid on anti-inflammatory action in mouse
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Kim Sang-Hyun
Lee Hyung-Seok
Byeon kwang-Seob
Lee Young-Joo
Hong Soon-Min
Choi Mee-Ra
Park Jun-Woo
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Abstract
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Purpose:The purpose of this study was not only to evaluate the relative mRNA expression of interleukin-1β(IL-1β), cyclooxygenase2 (COX-2) and prostaglandin E2 (PGE2) by RT-PCR analysis but to observe pattern of edema by light microscopic and electron microscope after topical apply of hyaluronic acid in inflammation-guided mouse.
Material and methods:Mice of this study were devided into 4 groups: Control group (no inflammation guided), Positive control (inflammation guided + vaselin apply), Protopic group (inflammation guided + protopic apply), Hyaluronic group (inflammation guided + hyaluronic acid apply).
Results:Hyaluronic group showed less expressions of IL-1β, COX-2, PGE2 than those of positive control & protopic group. Hyaluronic group revealed a decreased inflammation than positive control & protopic group in Light Microscope. Hyaluronic group appeared decreased edema of ear compare to positive control & protopic group in Elecron Microscope.
Conclusion:It was considered that hyaluronic acid has an antiinflammatory effect for intercepting the gene expression of cytokines related to inflammation.
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KEYWORD
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Hyaluronic acid, Anti-inflammatory agent, Mice
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